Pre-implantation genetic diagnosis (PGD)
Pre-implantation genetic diagnosis (PGD) is a procedure used to help identify genetic abnormalities in created embryos, aiming to prevent certain genetic diseases in new-borns.
In some cases, a genetically abnormal embryo may mature and even implant in the womb ending in abortion or a child born with a disorder. By performing PGD we can indetify these embryos before they are transfered, reducing the possibility of conceiving a child with a particular genetic factor.
Pre-implantation genetic diagnosis (PGD)
A biopsy is performed once embryos are formed. It is usually carried out on day three of embryo life, when they have 6-8 cells. Then one of these cells is retrieved using laser technology, not compromising their normal development. After the biopsy, embryos are maintained in vitro until the transfer.
Cells obtained from biopsied embryos are processed for a Next Generation Sequencing (NGS) genetic study. This tests for chromosomal aneuploidy, and also for translocations, inversions and other chromosomal abnormalities—both gains and loses, and/or for detection of embryos carrying certain monogenic inheritable diseases.
Once a PGD procedure has been performed and healthy day-5 embryos have been identified, those with the best morphological characteristics will be transfered.
- Women over 39 years of age.
- Sex-related genetic disease carriers.
- Single gene defect carriers.
- Those with chromosomal abnormalities (abnormal karyotypes)
- Women who have experienced recurrent pregnancy loss associated with chromosomal problems
PGD is also used for gender selection; however, this procedure is not permitted in our country.
ICSI + PGD Cost
*The price with donor sperm increases 435€
- Fixed Price: This is a fixed priced treatment that includes the services detailed on the cost breakdown. Supplementary tests may be required according to medical criteria, however, these will be notified in advance.
- Additional stimulations (oocyte accumulation): When supplementary stimulations are needed, an additional cost of 2,485€ per cycle will apply.
- Embryo devitrification: When an embryo transfer fails, an additional cost of 1,860 € will apply to subsecuent attempts.
- Validity: The validity of this estimate is 6 months from the date of your first consultation.
- Medication: Medication costs are not included. These will be assumed by the patient.
- Cancellation by the patient: In case of cancellation of the treatment, the patient must pay the costs incurred until that point.
- Transfer cancellation: When transfer needs to be cancelled due to embryos failing to evolve as expected, 220€ will be refunded.
- After 2 years of embryo cryopreservation: It will be your decision to either chose from one the authorised applications regarding embryo donation/destruction or the payment of a 435€ fee per year of conservation for future use.
- Sperm preservation: Sperm freezing has a cost of 250€, and 230€ per year of conservation.