Pre-implantation genetic diagnosis (PGD)

Pre-implantation genetic diagnosis (PGD) is a procedure used to help identify genetic abnormalities in created embryos, aiming to prevent certain genetic diseases in new-borns.

In some cases, a genetically abnormal embryo may mature and even implant in the womb ending in abortion or a child born with a disorder. By performing PGD we can indetify these embryos before they are transfered, reducing the possibility of conceiving a child with a particular genetic factor.

Pre-implantation genetic diagnosis (PGD)

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PGD starts with an in vitro fertilsation process, normally including: ovarian stimulation, oocyte retrieval and fertilisation in the laboratory. In the first three days the embryo is divided into 8 cells.

A biopsy is performed once embryos are formed. It is usually carried out on day three of embryo life, when they have 6-8 cells. Then one of these cells is retrieved using laser technology, not compromising their normal development.  After the biopsy, embryos are maintained in vitro until the transfer.

Cells obtained from biopsied embryos are processed for a Next Generation Sequencing (NGS) genetic study. This tests for chromosomal aneuploidy, and also for translocations, inversions and other chromosomal abnormalities—both gains and loses, and/or for detection of embryos carrying certain monogenic inheritable diseases.

Once a PGD procedure has been performed and healthy day-5 embryos have been identified, those with the best morphological characteristics will be transfered.

PGD will suit any couple at risk of transmitting a disease or genetic condition to their offspring. Here there is a list of potencial candidates for PGD:
  • Women over 39 years of age.
  • Sex-related genetic disease carriers.
  • Single gene defect carriers.
  • Those with chromosomal abnormalities (abnormal karyotypes)
  • Women who have experienced recurrent pregnancy loss associated with chromosomal problems

PGD is also used for gender selection; however, this procedure is not permitted in our country.

ICSI + PGD Cost

Phase
Previous Study
Stimulation
Follicular Puncture
Laboratory
Transfer
Post transfer
Embryo biopsy and NGS genetic study (unlimited number)

*The price with donor sperm increases 435€
Services included
Case-oriented cycle planning and all consultations
Ultrasound scans (unlimited)
Hormonal screenings (unlimited)
Puncture - follicular aspiration
Preoperative evaluation - anaesthesia - sedation
Rest in clinic
Laboratory procedures
IVF - ICSI
Sperm selection techniques, when necessary (embryo glue, MACS, PICSI, Microfluidic sperm sorting)
Assisted hatching included (when necessary)
Embryo culture (day 5-6) to blastocyst stage
Embryoscope+
KIDSCore / IDASCore (AI for embryo selection)
Embryo transfer (1 or 2 embryos)
Specific transfer techniques (when necessary)
Rest in clinic
Vitrification of spare embryos (unlimited number)
BHCG – pregnancy blood test (unlimited number)
Two pregnancy check-ups
Two years maintenance fee of vitrified embryos
Amount     5,985€
Amount    2,770€
Total Amount     8,755€
  • Fixed Price: This is a fixed priced treatment that includes the services detailed on the cost breakdown. Supplementary tests may be required according to medical criteria, however, these will be notified in advance.
  • Additional stimulations (oocyte accumulation): When supplementary stimulations are needed, an additional cost of 2,485€ per cycle will apply.
  • Embryo devitrification: When an embryo transfer fails, an additional cost of 1,860 € will apply to subsecuent attempts.
  • Validity: The validity of this estimate is 6 months from the date of your first consultation.
  • Medication: Medication costs are not included. These will be assumed by the patient.
  • Cancellation by the patient: In case of cancellation of the treatment, the patient must pay the costs incurred until that point.
  • Transfer cancellation: When transfer needs to be cancelled due to embryos failing to evolve as expected, 220€ will be refunded.
  • After 2 years of embryo cryopreservation: It will be your decision to either chose from one the authorised applications regarding embryo donation/destruction or the payment of a 435€ fee per year of conservation for future use.
  • Sperm preservation: Sperm freezing has a cost of 250€, and 230per year of conservation.
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