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Pre-implantation genetic diagnosis (PGD)

Pre-implantation genetic diagnosis (PGD) is a procedure used prior to implantation to help identify genetic defects in embryos created and prevent certain genetic diseases in new-borns.                                                                                                                                                            In some cases, a genetically defective embryo would mature and even implanted in the womb ending in abortion or, depending on the underlying genetic defect, born with the disorder. Using PGD we can detect these embryos to transfer, reducing the possibility of conceiving a child with a particular genetic factor.  

Pre-implantation genetic diagnosis (PGD) step by step:

Preimplantation genetic diagnosis begins with the in vitro fertilization process that normally includes: ovarian stimulation, oocyte retrieval and fertilization in the laboratory. In the first three days the embryo is divided to 8 cells.

Once we have the embryos in vitro, we proceed to the embryo biopsy. It is usually carried out on day three when embryos are divided into six-eight cells. Then a small hole with laser will be made to remove a cell without thereby compromising their normal development.  After the biopsy, the embryos were maintained in culture in vitro until transfer.

The cells obtained from biopsied embryos are processed for the genetic study by Array CGH technique. This is used to test for chromosomal aneuploidy, and also for translocations, inversions and other chromosomal abnormalities—both gains and losses, and/or to detect embryos that carry certain monogenic inheritable diseases. 

Once the PGD procedure has been performed and day 5 embryos free of genetic problems have been identified and presents better morphological characteristics will be placed back in the uterus.

Who can benefit from PGD?
Pre-implantation genetic diagnosis can benefit any couple at risk of transmitting a disease or genetic condition. The following is a list of the different types of people who are potential candidates for PGD:
  • Women over 39 years
  • The carriers of sex-linked genetic diseases
  • Carriers of a single gene defects
  • Those with chromosomal abnormalities (abnormal karyotypes)
  • Women who experience recurrent pregnancy loss associated with chromosomal problems

PGD is also used for gender selection; however, this procedure is not permitted in our country.

Budget ICSI + PGD

Previous Study
Follicular Puncture
Post transfer

*The price with donor sperm increases € 360
Services included
Case-oriented consultation and planning stage
Ultrasound scans (unlimited)
Hormonal controls (unlimited)
Puncture - follicular aspiration
Anaesthesia - sedation
Rest in clinic
Embryo transfer (1 or 2 embryos)
Rest in clinic
Surplus embryos vitrification (unlimited)
BHCG - analytical detection pregnancy (unlimited)
Check results
Vitrified embryos maintenance for 2 years
Amount     4.895€
Embryo biopsy and diagnostic Arrays
Amount    2.860
Total Amount     7.755€
  • Fixed Price: This budget has a fixed price. In some cases provided by medical prescription, a service and / or additional evidence not included in the budget may be necessary, but you would always be told in advance.
  • If you need additional stimulations (oocyte accumulation), each stack will have an additional amount of € 1,840.00
  • If an embryonic devitrification is needed, an additional cost of € 1,650 is required.
  • Validity: The validity of this budget is 6 months from the date of visit.
  • Medication: By law, the medication is not included and is borne by the patient.
  • Cancellation by the patient: In case of cancellation of treatment, the patient must pay the costs incurred until the stopping of
    such treatment.
  • In case that it doesn ́t reach the transfer for no evolution pre-embryonic, you will be credited € 160.00 in respect of such
    transfer not performed.
  • After the first 2 years from the pre-embryonic freezing: The patient must decide whether they wish to allocate the embryos to any legally authorised applications or if instead you want to pay the fee embryo maintenance.
  • If you need sperm freezing, it will have an additional amount of € 205.00

About IGIN Institute

IGIN Institute is a medical centre specialising in gynecology and assisted reproduction.
With its head office in Bilbao, in a modern infrastructure that provides its services using the latest technology without underestimating the human connection.